SEVERE PULMONARY HYPERSENSITIVITY ASSOCIATED WITH PASSIVE TRANSFUSION OF A NEUTROPHIL-SPECIFIC ANTIBODY

R. Yomtovian, C. Press, H. Engman, W. Kline, M. Clay, D. Hammerschmidt, J. Mccullough

Research output: Contribution to journalArticlepeer-review

130 Scopus citations

Abstract

A life-threatening pulmonary hypersensitivity reaction accompanied by profound leucopenia and transient hypocomplementaemia developed in a 73-year-old man after repair of an abdominal aortic aneurysm. A neutrophil-specific antibody, anti-NA2), was demonstrated by granulocyte immunofluorescence and microagglutination in one of the transfused donor units. In addition, activated complement component C5a was generated in vitro by incubation of the patient's serum with the aortic graft material. This severe clinical reaction may have resulted from the interaction of the transfused anti-NA2 antibody with complement activation induced by the aortic graft material.

Original languageEnglish (US)
Pages (from-to)244-246
Number of pages3
JournalThe Lancet
Volume323
Issue number8371
DOIs
StatePublished - Feb 4 1984

Bibliographical note

Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.

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