Sex and menstrual cycle differences in the subjective effects from smoked cocaine in humans

Mehmet Sofuoglu, Susan Dudish-Poulsen, David B Nelson, Paul R Pentel, Dorothy K Hatsukami

Research output: Contribution to journalArticlepeer-review

198 Scopus citations

Abstract

To investigate sex and menstrual cycle effects in response to cocaine administration, data from existing studies were analyzed. First, responses to a single delivery of 0.4 mg/kg smoked cocaine were investigated. Women reported lower ratings for measures of paranoid/suspicious and heart racing/pounding than did men. In addition, women in the luteal phase reported diminished ratings for a measure of feel high than did both women in the follicular phase of the menstrual cycle and men. Second, responses to up to 6 deliveries of 0.4 mg/kg smoked cocaine were investigated. Women, compared with men, had lower ratings on feel high, heart racing/pounding, and feel stimulated. Results suggest that there are significant sex and menstrual phase differences in the subjective effects of cocaine.

Original languageEnglish (US)
Pages (from-to)274-283
Number of pages10
JournalExperimental and Clinical Psychopharmacology
Volume7
Issue number3
DOIs
StatePublished - Aug 1999

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