Abstract
An efficient enantioselective synthesis of the antibacterials, linezolid (U-100766), and eperezolid (U-100592) using d-proline-catalyzed asymmetric α-aminooxylation of aldehydes as the key step is described here. This is the first report on the enantioselective synthesis of linezolid and eperezolid using asymmetric catalysis.
Original language | English (US) |
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Pages (from-to) | 6799-6802 |
Number of pages | 4 |
Journal | Tetrahedron Letters |
Volume | 47 |
Issue number | 38 |
DOIs | |
State | Published - Sep 18 2006 |
Externally published | Yes |
Bibliographical note
Funding Information:N.V.S.R. thanks CSIR, New Delhi, for the award of research fellowships. The authors are thankful to Dr. B. D. Kulkarni, Head, CEPD, for his support and encouragement.