Shortened cortical silent period in adductor spasmodic dysphonia: Evidence for widespread cortical excitability

Sharyl Samargia; Rebekah Schmidt; Teresa J Kimberley, PT,

doi:10.1016/j.neulet.2013.12.007

Shortened cortical silent period in adductor spasmodic dysphonia: Evidence for widespread cortical excitability

Sharyl Samargia, Rebekah Schmidt, Teresa J Kimberley, PT,

Physical Therapy

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31 Scopus citations

Abstract

The purpose of this study was to compare cortical inhibition in the hand region of the primary motor cortex between subjects with focal hand dystonia (FHD), adductor spasmodic dysphonia (AdSD), and healthy controls. Data from 28 subjects were analyzed (FHD n=11, 53.25. ±. 8.74. y; AdSD: n=8, 56.38. ±. 7.5. y; and healthy controls: n=941.67. ±. 10.85. y). All subjects received single pulse TMS to the left motor cortex to measure cortical silent period (CSP) in the right first dorsal interosseus (FDI) muscle. Duration of the CSP was measured and compared across groups. A one-way ANCOVA with age as a covariate revealed a significant group effect (p<. 0.001). Post hoc analysis revealed significantly longer CSP duration in the healthy group vs. AdSD group (p<. 0.001) and FHD group (p<. 0.001). These results suggest impaired intracortical inhibition is a neurophysiologic characteristic of FHD and AdSD. In addition, the shortened CSP in AdSD provides evidence to support a widespread decrease in cortical inhibition in areas of the motor cortex that represent an asymptomatic region of the body. These findings may inform future investigations of differential diagnosis as well as alternative treatments for focal dystonias.

Original language	English (US)
Pages (from-to)	12-15
Number of pages	4
Journal	Neuroscience Letters
Volume	560
DOIs	https://doi.org/10.1016/j.neulet.2013.12.007
State	Published - Feb 7 2014

Bibliographical note

Funding Information:
Research reported in this publication was partially supported by the Dystonia Medical Research Foundation and the National Center for Advancing Translational Sciences of the National Institutes of Health Award Number UL1TR000114 . The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. The authors gratefully acknowledge the efforts of Matthew Moore, DPT; Sandra Gress, DPT; Elizabeth Lauer, DPT; Meredith Lorig, BS; Andrea Mallas, DPT; Andrea Meidl, DPT; Natasha Meister, DPT; Daniel Monroe, DPT; Chad Morlock, DPT; Rachel Oliver, DPT.

Keywords

Adductor spasmodic dysphonia
Cortical silent period
Focal hand dystonia
Transcranial magnetic stimulation

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title = "Shortened cortical silent period in adductor spasmodic dysphonia: Evidence for widespread cortical excitability",

abstract = "The purpose of this study was to compare cortical inhibition in the hand region of the primary motor cortex between subjects with focal hand dystonia (FHD), adductor spasmodic dysphonia (AdSD), and healthy controls. Data from 28 subjects were analyzed (FHD n=11, 53.25. ±. 8.74. y; AdSD: n=8, 56.38. ±. 7.5. y; and healthy controls: n=941.67. ±. 10.85. y). All subjects received single pulse TMS to the left motor cortex to measure cortical silent period (CSP) in the right first dorsal interosseus (FDI) muscle. Duration of the CSP was measured and compared across groups. A one-way ANCOVA with age as a covariate revealed a significant group effect (p<. 0.001). Post hoc analysis revealed significantly longer CSP duration in the healthy group vs. AdSD group (p<. 0.001) and FHD group (p<. 0.001). These results suggest impaired intracortical inhibition is a neurophysiologic characteristic of FHD and AdSD. In addition, the shortened CSP in AdSD provides evidence to support a widespread decrease in cortical inhibition in areas of the motor cortex that represent an asymptomatic region of the body. These findings may inform future investigations of differential diagnosis as well as alternative treatments for focal dystonias.",

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N2 - The purpose of this study was to compare cortical inhibition in the hand region of the primary motor cortex between subjects with focal hand dystonia (FHD), adductor spasmodic dysphonia (AdSD), and healthy controls. Data from 28 subjects were analyzed (FHD n=11, 53.25. ±. 8.74. y; AdSD: n=8, 56.38. ±. 7.5. y; and healthy controls: n=941.67. ±. 10.85. y). All subjects received single pulse TMS to the left motor cortex to measure cortical silent period (CSP) in the right first dorsal interosseus (FDI) muscle. Duration of the CSP was measured and compared across groups. A one-way ANCOVA with age as a covariate revealed a significant group effect (p<. 0.001). Post hoc analysis revealed significantly longer CSP duration in the healthy group vs. AdSD group (p<. 0.001) and FHD group (p<. 0.001). These results suggest impaired intracortical inhibition is a neurophysiologic characteristic of FHD and AdSD. In addition, the shortened CSP in AdSD provides evidence to support a widespread decrease in cortical inhibition in areas of the motor cortex that represent an asymptomatic region of the body. These findings may inform future investigations of differential diagnosis as well as alternative treatments for focal dystonias.

AB - The purpose of this study was to compare cortical inhibition in the hand region of the primary motor cortex between subjects with focal hand dystonia (FHD), adductor spasmodic dysphonia (AdSD), and healthy controls. Data from 28 subjects were analyzed (FHD n=11, 53.25. ±. 8.74. y; AdSD: n=8, 56.38. ±. 7.5. y; and healthy controls: n=941.67. ±. 10.85. y). All subjects received single pulse TMS to the left motor cortex to measure cortical silent period (CSP) in the right first dorsal interosseus (FDI) muscle. Duration of the CSP was measured and compared across groups. A one-way ANCOVA with age as a covariate revealed a significant group effect (p<. 0.001). Post hoc analysis revealed significantly longer CSP duration in the healthy group vs. AdSD group (p<. 0.001) and FHD group (p<. 0.001). These results suggest impaired intracortical inhibition is a neurophysiologic characteristic of FHD and AdSD. In addition, the shortened CSP in AdSD provides evidence to support a widespread decrease in cortical inhibition in areas of the motor cortex that represent an asymptomatic region of the body. These findings may inform future investigations of differential diagnosis as well as alternative treatments for focal dystonias.

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KW - Transcranial magnetic stimulation

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Shortened cortical silent period in adductor spasmodic dysphonia: Evidence for widespread cortical excitability

Abstract

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Keywords

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