Shrink-induced graphene sensor for alpha-fetoprotein detection with low-cost self-assembly and label-free assay

Shota Sando, Bo Zhang, Tianhong Cui

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Combination of shrink induced nano-composites technique and layer-by-layer (LbL) self-assembled graphene challenges controlling surface morphology. Adjusting shrink temperature achieves tunability on graphene surface morphology on shape memory polymers, and it promises to be an alternative in fields of high-surface-area conductors and molecular detection. In this study, self-assembled graphene on a shrink polymer substrate exhibits nanowrinkles after heating. Induced nanowrinkles on graphene with different shrink temperature shows distinct surface roughness and wettability. As a result, it becomes more hydrophilic with higher shrink temperatures. The tunable wettability promises to be utilized in, for example, microfluidic devices. The graphene on shrink polymer also exhibits capability of being used in sensing applications for pH and alpha-fetoprotein (AFP) detection with advantages of label free and low cost, due to self-assembly technique, easy functionalization, and antigen-antibody reaction on graphene surface. The detection limit of AFP detection is down to 1 pg/mL, and therefore the sensor also has a significant potential for biosensing as it relies on low-cost self-assembly and label-free assay.

Original languageEnglish (US)
Pages (from-to)574-580
Number of pages7
JournalFrontiers of Mechanical Engineering
Issue number4
StatePublished - Dec 1 2017

Bibliographical note

Publisher Copyright:
© 2017, The Author(s).


  • AFP
  • biosensor
  • graphene
  • label-free
  • self-assembly
  • shrink polymer


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