SHROOM3-FYN Interaction Regulates Nephrin Phosphorylation and Affects Albuminuria in Allografts

J. M. Basgen

doi:10.1681/ASN.2018060573

SHROOM3-FYN Interaction Regulates Nephrin Phosphorylation and Affects Albuminuria in Allografts

J. M. Basgen

University Imaging Centers

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Abstract

We previously showed that the presence of a CKD-associated locus in SHROOM3 in a donor kidney results in increased expression of SHROOM3 (an F-actin–binding protein important for epithelial morphogenesis, via rho-kinase [ROCK] binding); this facilitates TGF-b signaling and allograft fibrosis. However, other evidence suggests Shroom3 may have a protective role in glomerular development.

Original language	English (US)
Journal	Journal of the American Society of Nephrology : JASN
Volume	29
Issue number	11
DOIs	https://doi.org/10.1681/ASN.2018060573
State	Published - Oct 31 2018

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Mark A Sanders (Program Director) & Guillermo Marques (Scientific Director)
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SHROOM3-FYN Interaction Regulates Nephrin Phosphorylation and Affects Albuminuria in Allografts

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