Signs and symptoms from nicotine gum abstinence

Dorothy K. Hatsukami, Kelli Skoog, Marguerite Huber, John Hughes

Research output: Contribution to journalArticlepeer-review

15 Scopus citations


This study examined and compared withdrawal signs and symptoms from cessation of 0, 2 and 4 mg nicotine gum. In addition, a comparison was made between nicotine gum versus cigarette withdrawal symptoms. Smokers first underwent cigarette deprivation for 4 days and then were randomly assigned to 0 (N=16), 2 (N=25), and 4 (N=21) mg gum. They were asked to chew the gum for 1 month and then to undergo a 4-day nicotine gum deprivation period. The results showed a number of significant changes occurring after deprivation from 4 mg gum, one change from 2 mg gum, and no changes from 0 mg gum. There were no significant differences in severity of withdrawal among the various doses of nicotine gum. There were more severe symptoms of withdrawal from cigarette as opposed to 4 mg nicotine gum deprivation.

Original languageEnglish (US)
Pages (from-to)496-504
Number of pages9
Issue number4
StatePublished - Aug 1991


  • Cigarette
  • Nicotine gum
  • Withdrawal

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