Sinus histiocytosis with massive lymphadenopathy (rosai‐dorfman disease): Diagnosis by fine‐needle aspiration

Bruce C. Trautman, Michael W. Stanley, George Goding, Juan Rosai

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Abstract

Sinus histiocytosis with massive lymphadenopathy (SHML) is a rare idiopathic proliferative disorder of histiocytes with characteristic morphologic features. We describe a case of SHML occurring in a 14‐yr‐old black male, in whom the diagnosis was made by fine‐needle aspiration of a cervical lymph node. Cytologic features included increased numbers of large histiocytes associated with a polymorphous, cellular background composed of benign lymphocytes, plasma cells, and polymorphonuclear leukocytes. Lymphophagocytosis was a prominent feature. Extranodal involvement of the larynx was documented by surgical biopsy; there was no other extranodal disease. One year after diagnosis, the patient is clinically well, with no residual lymphadenopathy.

Original languageEnglish (US)
Pages (from-to)513-516
Number of pages4
JournalDiagnostic Cytopathology
Volume7
Issue number5
DOIs
StatePublished - Sep 1991

Keywords

  • Histiocyte
  • Larynx
  • Lymph node
  • Lympho‐phagocytosis
  • SHML

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