siRNAs: their potential as therapeutic agents - Part II. Methods of delivery

Sunit Kumar Singh, Praveensingh B. Hajeri

Research output: Contribution to journalReview articlepeer-review

28 Scopus citations

Abstract

RNA interference (RNAi) is a sequence-specific mechanism to control the expression of target genes. This technique has proven potentials both in vivo and in vitro. The main hurdle for using RNAi-based therapy is the effective delivery of RNAi-based drugs to the target cells or tissues in vivo. The aspects of off-target effects, delivery methods, induction of immune response and dose determination for delivery should, however, be considered carefully. If these challenges associated with siRNA can be met, then the potentials of RNAi could be exploited to the full for the development of therapeutic tools and drugs.

Original languageEnglish (US)
Pages (from-to)859-865
Number of pages7
JournalDrug Discovery Today
Volume14
Issue number17-18
DOIs
StatePublished - Sep 2009

Bibliographical note

Funding Information:
Authors are highly thankful to Dr Lalji Singh, Director, Centre for Cellular & Molecular Biology (CCMB), Hyderabad for providing all the necessary support during the preparation of this manuscript. The financial support (Ref: BT/PR10709/AGR/36/598/2008) from the Department of Biotechnology (DBT), Govt. of India, New Delhi is highly acknowledged.

Copyright:
Copyright 2009 Elsevier B.V., All rights reserved.

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