Sleep onset problems and subcortical development in infants later diagnosed with autism spectrum disorder

Katherine E. MacDuffie, Mark D. Shen, Stephen R. Dager, Martin A. Styner, Sun Hyung Kim, Sarah Paterson, Juhi Pandey, Tanya St John, Jed T. Elison, Jason J. Wolff, Meghan R. Swanson, Kelly N. Botteron, Lonnie Zwaigenbaum, Joseph Piven, Annette M. Estes

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Objective: Sleep patterns in children with autism spectrum disorder (ASD) appear to diverge from typical development in the second or third year of life. Little is known, however, about the occurrence of sleep problems in infants who later develop ASD and possible effects on early brain development. In a longitudinal neuroimaging study of infants at familial high or low risk for ASD, parent-reported sleep onset problems were examined in relation to subcortical brain volumes in the first 2 years of life. Methods: A total of 432 infants were included across three study groups: infants at high risk who developed ASD (N=71), infants at high risk who did not develop ASD (N=234), and infants at low risk (N=127). Sleep onset problem scores (derived from an infant temperament measure) were evaluated in relation to longitudinal high-resolution T1 and T2 structural imaging data acquired at 6, 12, and 24 months of age. Results: Sleep onset problems were more common at 6–12 months among infants who later developed ASD. Infant sleep onset problems were related to hippocampal volume trajectories from 6 to 24 months only for infants at high risk who developed ASD. Brain-sleep relationships were specific to the hippocampus; no significant relationships were found with volume trajectories of other subcortical structures examined (the amygdala, caudate, globus pallidus, putamen, and thalamus). Conclusions: These findings provide initial evidence that sleep onset problems in the first year of life precede ASD diagnosis and are associated with altered neurodevelopmental trajectories in infants at high familial risk who go on to develop ASD. If replicated, these findings could provide new insights into a potential role of sleep difficulties in the development of ASD.

Original languageEnglish (US)
Pages (from-to)518-525
Number of pages8
JournalAmerican Journal of Psychiatry
Volume177
Issue number6
DOIs
StatePublished - Jun 2020

Bibliographical note

Funding Information:
Drs. Piven and Estes share senior authorship. Presented in part as a poster at the annual meeting of the International Society for Autism Research, May 1–4 2019, Montreal. Supported by the NIH Autism Center of Excellence (NIMH and Eunice Kennedy Shriver National Institute of Child Health and Human Development grant HD055741 to Dr. Piven), Autism Speaks (grant 6020), and the Simons Foundation (grant 140209), as well as NIMH (grant F32MH118689 to Dr. MacDuffie).

Publisher Copyright:
© 2020 American Psychiatric Association. All rights reserved.

PubMed: MeSH publication types

  • Journal Article
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

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