Smoking and risk of coronary heart disease in younger, middle-aged, and older adults

Janne S. Tolstrup, Ulla A. Hvidtfeldt, Esben Meulengracht Flachs, Donna Spiegelman, Berit L. Heitmann, Katarina Bälter, Uri Goldbourt, Göran Hallmans, Paul Knekt, Simin Liu, Mark Pereira, June Stevens, Jarmo Virtamo, Diane Feskanich

Research output: Contribution to journalArticlepeer-review

33 Scopus citations


Objectives: We investigated associations of smoking and coronary heart disease (CHD) by age. Methods: Data came from the Pooling Project on Diet and Coronary Heart Disease (8 prospective studies, 1974-1996; n = 192 067 women and 74 720 men, aged 40-89 years). Results: During follow-up, 4326 cases of CHD were reported. Relative to never smokers, CHD risk among current smokers was highest in the youngest and lowest in the oldest participants. For example, among women aged 40 to 49 years the hazard ratio was 8.5 (95% confidence interval [CI]= 5.0, 14) and 3.1 (95% CI = 2.0, 4.9) among those aged 70 years or older. The largest absolute risk differences between current smokers and never smokers were observed among the oldest participants. Finally, the majority of CHD cases among smokers were attributable to smoking. For example, attributable proportions of CHD by age group were 88% (40-49 years), 81% (50-59 years), 71% for (60-69 years), and 68% (≥70 years) among women who smoked. Conclusions: Among smokers, the majority of CHD cases are attributable to smoking in all age groups. Smoking prevention is important, irrespective of age.

Original languageEnglish (US)
Pages (from-to)96-102
Number of pages7
JournalAmerican journal of public health
Issue number1
StatePublished - Jan 2014

Fingerprint Dive into the research topics of 'Smoking and risk of coronary heart disease in younger, middle-aged, and older adults'. Together they form a unique fingerprint.

Cite this