Frequency and durational components of smoking topography were measured by a portable smoking device while 10 subjects smoked four cigarettes ad libitum in a non-laboratory environment. Nicotine blood levels were measured before and after smoking each cigarette and serial blood samples for determining nicotine metabolic half-life were obtained the following day. Results showed that change in pre- and post-cigarette nicotine levels and metabolic half-life for nicotine were not related to within-cigarette topography measures or nicotine yield of cigarette, but were significantly related to intercigarette interval.
Bibliographical noteFunding Information:
Research supported by NIDA Research Grants DA 02988-04 and DA 02413 and grant RR-400 from the Clinical Research Centers Program of the Division of Research Resources, National Institutes of Health. Requests for reprints should be sent to Dorothy K. Hatsukami, PhD, Department of Psychiatry, Box 393 Mayo. University of Minnesota, Minneapolis, MN 55455. 91