SNP-based heritability and genetic architecture of cranial cruciate ligament rupture in Labrador Retrievers

S. R. Cook; M. G. Conzemius; M. E. McCue; K. J. Ekenstedt

doi:10.1111/age.12978

SNP-based heritability and genetic architecture of cranial cruciate ligament rupture in Labrador Retrievers

S. R. Cook, M. G. Conzemius, M. E. McCue, K. J. Ekenstedt

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12 Scopus citations

Abstract

Cranial cruciate ligament rupture (CCLR) is one of the leading causes of pelvic limb lameness in dogs. About 6% of Labrador Retrievers suffer from this orthopedic problem. The aim of this study was to determine the heritability of CCLR in this breed using SNP array genotyping data. DNA samples were collected from CCLR-affected dogs (n = 190) and unaffected dogs over the age of 8 years (n = 143). All 333 dogs were genotyped directly or imputed up to approximately 710k SNPs on the Affymetrix Axiom CanineHD SNP array. Heritability of CCLR was calculated using multiple methodologies, including linear mixed models, Bayesian models and a model that incorporates LD. The covariates of sex and sterilization status were added to each analysis to assess their impact. Across the algorithms of these models, heritability ranged from 0.550 to 0.886, depending on covariate inclusion. The relatively high heritability for this disease indicates that a substantial genetic component contributes to CCLR in the Labrador Retriever.

Original language	English (US)
Pages (from-to)	824-828
Number of pages	5
Journal	Animal Genetics
Volume	51
Issue number	5
DOIs	https://doi.org/10.1111/age.12978
State	Published - Oct 1 2020

Bibliographical note

Funding Information:
The authors gratefully acknowledge methodological assistance from Dr Luiz Brito and Dr Elaine Norton. Partial support for KJE was provided by the Office of the Director, National Institutes of Health under award number K01‐OD027051. Other support came from the Veterinary Orthopedic Society, the Tata Group Endowment at the University of Minnesota and the Bernice Barbour Foundation.

Funding Information:
The authors gratefully acknowledge methodological assistance from Dr Luiz Brito and Dr Elaine Norton. Partial support for KJE was provided by the Office of the Director, National Institutes of Health under award number K01-OD027051. Other support came from the Veterinary Orthopedic Society, the Tata Group Endowment at the University of Minnesota and the Bernice Barbour Foundation.

Publisher Copyright:
© 2020 Stichting International Foundation for Animal Genetics

Keywords

anterior cruciate ligament
canine
covariates
dog
heritability programs

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title = "SNP-based heritability and genetic architecture of cranial cruciate ligament rupture in Labrador Retrievers",

abstract = "Cranial cruciate ligament rupture (CCLR) is one of the leading causes of pelvic limb lameness in dogs. About 6% of Labrador Retrievers suffer from this orthopedic problem. The aim of this study was to determine the heritability of CCLR in this breed using SNP array genotyping data. DNA samples were collected from CCLR-affected dogs (n = 190) and unaffected dogs over the age of 8 years (n = 143). All 333 dogs were genotyped directly or imputed up to approximately 710k SNPs on the Affymetrix Axiom CanineHD SNP array. Heritability of CCLR was calculated using multiple methodologies, including linear mixed models, Bayesian models and a model that incorporates LD. The covariates of sex and sterilization status were added to each analysis to assess their impact. Across the algorithms of these models, heritability ranged from 0.550 to 0.886, depending on covariate inclusion. The relatively high heritability for this disease indicates that a substantial genetic component contributes to CCLR in the Labrador Retriever.",

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SNP-based heritability and genetic architecture of cranial cruciate ligament rupture in Labrador Retrievers

Abstract

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The Importance of Genetics in Leading Orthopedic Problem in Dogs

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SNP-based heritability and genetic architecture of cranial cruciate ligament rupture in Labrador Retrievers

Abstract

Bibliographical note

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The Importance of Genetics in Leading Orthopedic Problem in Dogs

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