TY - JOUR
T1 - Social attainment in survivors of pediatric central nervous system tumors
T2 - a systematic review and meta-analysis from the Children’s Oncology Group
AU - Schulte, Fiona
AU - Kunin-Batson, Alicia S.
AU - Olson-Bullis, Barbara A.
AU - Banerjee, Pia
AU - Hocking, Matthew C.
AU - Janzen, Laura
AU - Kahalley, Lisa S.
AU - Wroot, Hayley
AU - Forbes, Caitlin
AU - Krull, Kevin R.
N1 - Funding Information:
This work was supported in part by the Children’s Oncology Group grant U10CA180886 from the National Cancer Institute and the St. Baldrick’s Foundation.
Publisher Copyright:
© 2019, Springer Science+Business Media, LLC, part of Springer Nature.
PY - 2019/12/1
Y1 - 2019/12/1
N2 - Purpose: Improved therapies for pediatric central nervous system (CNS) tumors have increased survival rates; however, many survivors experience significant long-term functional limitations. Survivors of pediatric CNS tumors can experience deficits in social attainment. The aim of this review was to systematically amalgamate findings pertaining to social attainment (i.e., educational attainment, marriage, employment outcomes) in survivors of pediatric CNS tumors. Methods: PubMed (web-based), PsycINFO (EBSCO), EMBASE (Ovid), and Web of Science (Thomson Reuters) were used to identify articles published between January 2011 and September 2018. Eligible studies reported outcomes for survivors of pediatric CNS tumors diagnosed before age 21 years and > 5 years from diagnosis and/or > 2 years off therapy. All data were independently abstracted by two reviewers. Random-effects meta-analyses were performed using Review Manager 5.0. Results: The search yielded 7021 unique publications. Forty-six were included in the current review. Meta-analyses revealed survivors of CNS tumors were significantly more likely to have completed compulsory education only (OR = 1.87, 95% CI = 1.66, 2.12, p < 0.00001), less likely to be married (OR = 4.70, 95% CI = 3.89, 5.68, p < 0.00001), and more likely to be unemployed (OR = 2.84, 95% CI = 2.62, 3.08, p < 0.00001) compared to non-cancer controls. Cranial radiation therapy, neurocognitive deficits, and younger age at diagnosis were associated with poorer outcomes. Hearing loss and bilateral blindness were also related to poorer outcomes. Sex did not impact social attainment outcomes. Conclusions: Survivors of pediatric CNS tumors are at elevated risk for poor attainment of key adult social outcomes. Implications for Cancer Survivors: There is a critical need to develop interventions to support survivors in becoming independent and productive adults.
AB - Purpose: Improved therapies for pediatric central nervous system (CNS) tumors have increased survival rates; however, many survivors experience significant long-term functional limitations. Survivors of pediatric CNS tumors can experience deficits in social attainment. The aim of this review was to systematically amalgamate findings pertaining to social attainment (i.e., educational attainment, marriage, employment outcomes) in survivors of pediatric CNS tumors. Methods: PubMed (web-based), PsycINFO (EBSCO), EMBASE (Ovid), and Web of Science (Thomson Reuters) were used to identify articles published between January 2011 and September 2018. Eligible studies reported outcomes for survivors of pediatric CNS tumors diagnosed before age 21 years and > 5 years from diagnosis and/or > 2 years off therapy. All data were independently abstracted by two reviewers. Random-effects meta-analyses were performed using Review Manager 5.0. Results: The search yielded 7021 unique publications. Forty-six were included in the current review. Meta-analyses revealed survivors of CNS tumors were significantly more likely to have completed compulsory education only (OR = 1.87, 95% CI = 1.66, 2.12, p < 0.00001), less likely to be married (OR = 4.70, 95% CI = 3.89, 5.68, p < 0.00001), and more likely to be unemployed (OR = 2.84, 95% CI = 2.62, 3.08, p < 0.00001) compared to non-cancer controls. Cranial radiation therapy, neurocognitive deficits, and younger age at diagnosis were associated with poorer outcomes. Hearing loss and bilateral blindness were also related to poorer outcomes. Sex did not impact social attainment outcomes. Conclusions: Survivors of pediatric CNS tumors are at elevated risk for poor attainment of key adult social outcomes. Implications for Cancer Survivors: There is a critical need to develop interventions to support survivors in becoming independent and productive adults.
KW - CNS tumors
KW - Pediatric
KW - Social attainment
KW - Survivorship
KW - Systematic review
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U2 - 10.1007/s11764-019-00808-3
DO - 10.1007/s11764-019-00808-3
M3 - Review article
C2 - 31625086
AN - SCOPUS:85074519066
SN - 1932-2259
VL - 13
SP - 921
EP - 931
JO - Journal of Cancer Survivorship
JF - Journal of Cancer Survivorship
IS - 6
ER -
