Sodium nitroprusside enhanced cardiopulmonary resuscitation (SNPeCPR) improves vital organ perfusion pressures and carotid blood flow in a porcine model of cardiac arrest

Jason Schultz, Nicolas Segal, James Kolbeck, Scott McKnite, Emily Caldwell, Demetris Yannopoulos

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

Purpose of the study: To describe a new method of CPR that optimizes vital organ perfusion pressures and carotid blood flow. We tested the hypothesis that a combination of high dose sodium nitroprusside (SNP) as well as non-invasive devices and techniques known independently to enhance circulation would significantly improve carotid blood flow (CBF) and return of spontaneous circulation (ROSC) rates in a porcine model of cardiac arrest. Methods: 15 isofluorane anesthetized pigs (30 ± 1. kg), after 6. min of untreated ventricular fibrillation, were subsequently randomized to receive either 15. min of standard CPR (S-CPR) (8 animals) or 5. min epochs of S-CPR followed by active compression-decompression (ACD) + inspiratory impedance threshold device (ITD) CPR followed by ACD + ITD + abdominal binding (AB) with 1. mg of SNP administered at minutes 2, 7, 12 of CPR (7 animals). Primary endpoints were CBF and ROSC rates. ANOVA and Fisher's exact test were used for comparisons. Results/conclusion: There was significant improvement in the hemodynamic parameters in the SNP animals. ROSC was achieved in 7/7 animals that received SNP and in 2/8 in the S-CPR (p=0.007). CBF and end tidal CO 2 (ETCO 2) were significantly higher in the ACD+ITD+AB+SNP (SNPeCPR) animals during CPR. Bolus doses of SNP, when used in conjunction with ACD+ITD+AB CPR, significantly improve CBF and ROSC rates compared to S-CPR.

Original languageEnglish (US)
Pages (from-to)374-377
Number of pages4
JournalResuscitation
Volume83
Issue number3
DOIs
StatePublished - Mar 2012

Keywords

  • CPR
  • Carotid blood flow
  • Resuscitation rates
  • Vasodilators

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