Peptide aldehydes were synthesized, starting from amino acetals, by a Solid-phase backbone amide linker (BAL) strategy.
Bibliographical noteFunding Information:
We are grateful to Annette Nordestgaard from Phytera Symbion for LC/MS analyses, and Professor Fernando Albericio for valuable discussions. We thank the Leo Foundation (K.J.), the Lundbeck Foundation (K.J.), and the NIH (GM 42722 to GB) for financial support. J.K. was supported by an NIH Biotechnology Training Grant (GM 08347).
- Amino acetals
- Peptide aldehydes
- Solid-phase synthesis