TY - JOUR
T1 - Solitary oral epidermolytic acanthoma
T2 - Case report of a rarely diagnosed entity
AU - Argyris, Prokopios P.
AU - Slama, Zachary M.
AU - Nelson, Andrew C.
AU - Koutlas, Ioannis G.
N1 - Publisher Copyright:
© 2019 Elsevier Inc.
PY - 2019/12
Y1 - 2019/12
N2 - Epidermolytic acanthoma represents a rare localized form of epidermolytic hyperkeratosis, which resembles warty lesions and shows a strong predilection for the genital skin of males. Here, we present an oral solitary epidermolytic acanthoma affecting a 71-year-old Caucasian man. Clinically, the lesion was white, well-circumscribed, and sessile, measuring 2 mm in diameter and located on the posterior mandibular buccal gingiva. Microscopically, pronounced hyperkeratosis and acanthosis, with formation of keratin crypts was observed. Lesional cells of the spinous and granular epithelial layers exhibited prominent intracellular vacuolar degeneration, as well as eosinophilic paranuclear and perinuclear condensations. Intracytoplasmic eosinophilic globules were also seen. No recurrences have been reported. Investigation for low- and high-risk human papillomavirus (HPV) infection failed to reveal positivity for HPV subtypes 6, 11, 16, and 18. Literature review revealed scarce reports of epidermolytic hyperkeratosis–like changes of the oral mucosa associated with malignant neoplasms and inflammatory processes. Epidermolytic acanthoma should be considered in the differential diagnosis of benign epithelial papillomatous lesions of the oral cavity.
AB - Epidermolytic acanthoma represents a rare localized form of epidermolytic hyperkeratosis, which resembles warty lesions and shows a strong predilection for the genital skin of males. Here, we present an oral solitary epidermolytic acanthoma affecting a 71-year-old Caucasian man. Clinically, the lesion was white, well-circumscribed, and sessile, measuring 2 mm in diameter and located on the posterior mandibular buccal gingiva. Microscopically, pronounced hyperkeratosis and acanthosis, with formation of keratin crypts was observed. Lesional cells of the spinous and granular epithelial layers exhibited prominent intracellular vacuolar degeneration, as well as eosinophilic paranuclear and perinuclear condensations. Intracytoplasmic eosinophilic globules were also seen. No recurrences have been reported. Investigation for low- and high-risk human papillomavirus (HPV) infection failed to reveal positivity for HPV subtypes 6, 11, 16, and 18. Literature review revealed scarce reports of epidermolytic hyperkeratosis–like changes of the oral mucosa associated with malignant neoplasms and inflammatory processes. Epidermolytic acanthoma should be considered in the differential diagnosis of benign epithelial papillomatous lesions of the oral cavity.
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U2 - 10.1016/j.oooo.2019.03.016
DO - 10.1016/j.oooo.2019.03.016
M3 - Article
C2 - 31078506
AN - SCOPUS:85065124833
SN - 2212-4403
VL - 128
SP - e208-e213
JO - Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
JF - Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
IS - 6
ER -