Solubility properties of chlorhexidine salts

Pengyung Zeng, Aruna Rao, Timothy Scott Wiedmann, Walter Bowles

Research output: Contribution to journalArticlepeer-review

18 Scopus citations


Chlorhexidine (CHX) is effective in treating oral bacterial infections. The solubility was shown to be highly dependent on the salt present in solution. Gluconate enhances the amount of CHX diacetate in solution possibly through mixed micelles formation, because the solubility product is such that the concentration of CHX will exceed the critical micelle concentration. However, only low concentrations of CHX dichloride can be obtained, which is not appreciably solubilized by gluconate ions. The low concentration of CHX that can be achieved in physiological concentrations of chloride in the oral cavity may be problematic for dental, slow release formulations.

Original languageEnglish (US)
Pages (from-to)172-176
Number of pages5
JournalDrug Development and Industrial Pharmacy
Issue number2
StatePublished - Feb 2009

Bibliographical note

Funding Information:
This work was supported in part by a grant from the Academic Health Center, University Of Minnesota.


  • Chlorhexidine
  • Chlorhexidine diacetate
  • Chlorhexidine dichloride
  • Chlorhexidine digluconate
  • Micelle
  • Solubility product

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