log k† values on a C18 stationary phase with 90/10, 75/25, 60/40, 45/55 and 30/70 methanol-water mobile phases are correlated in terms of the generalized linear solvation energy relationship, log k' = XYZo + mV1/100 + sπ* + bβm + aαm where V1 is the intrinsic (van der Waals) molar volume, and π*, βm, and αm are the solvatochromic parameters that measure solute dipolarity-polarizability, hydrogen-bond acceptor basicity, and hydrogen-bond donor acidity. The correlation equations are combined with the corresponding equation for octanol-water partition coefficients to generate new equations that demonstrate the exact relationships between the various log k's and log Kow.
|Original language||English (US)|
|Number of pages||6|
|Journal||Journal of the Chemical Society, Perkin Transactions 2|
|State||Published - Jan 1 1988|