Solute-solvent interactions in chemistry and biology. Part 7. An analysis of mobile phase effects on high pressure liquid chromatography capacity factors and relationships of the latter with octanol-water partition coefficients

Mortimer J. Kamlet, Michael H. Abraham, Peter W Carr, Ruth M. Doherty, Robert W. Taft

Research output: Contribution to journalArticlepeer-review

81 Scopus citations

Abstract

log k† values on a C18 stationary phase with 90/10, 75/25, 60/40, 45/55 and 30/70 methanol-water mobile phases are correlated in terms of the generalized linear solvation energy relationship, log k' = XYZo + mV1/100 + sπ* + bβm + aαm where V1 is the intrinsic (van der Waals) molar volume, and π*, βm, and αm are the solvatochromic parameters that measure solute dipolarity-polarizability, hydrogen-bond acceptor basicity, and hydrogen-bond donor acidity. The correlation equations are combined with the corresponding equation for octanol-water partition coefficients to generate new equations that demonstrate the exact relationships between the various log k's and log Kow.

Original languageEnglish (US)
Pages (from-to)2087-2092
Number of pages6
JournalJournal of the Chemical Society, Perkin Transactions 2
Issue number12
DOIs
StatePublished - Jan 1 1988

Fingerprint Dive into the research topics of 'Solute-solvent interactions in chemistry and biology. Part 7. An analysis of mobile phase effects on high pressure liquid chromatography capacity factors and relationships of the latter with octanol-water partition coefficients'. Together they form a unique fingerprint.

Cite this