TY - JOUR
T1 - Soudanones A-G
T2 - Antifungal Isochromanones from the Ascomycetous Fungus Cadophora sp. Isolated from an Iron Mine
AU - Rusman, Yudi
AU - Held, Benjamin W.
AU - Blanchette, Robert A.
AU - Wittlin, Sergio
AU - Salomon, Christine E.
N1 - Publisher Copyright:
© 2015 The American Chemical Society and American Society of Pharmacognosy.
PY - 2015/6/26
Y1 - 2015/6/26
N2 - One new isochromane (pseudoanguillosporin C, 2), seven isochromanones (soudanones A-G, 3-9), and six known analogues including 10 and 11 were isolated from a culture of the fungus Cadophora sp. 10-5-2 M, collected from the subterranean 10th level of the Soudan Underground Iron Mine in Minnesota. All of the compounds were tested against a panel of microbial pathogens, and 2, 3, 10, and 11 were found to have activity against Cryptococcus neoformans (MIC = 35, 40, 20, and 30 μg/mL, respectively). Compound 11 was also active against Candida albicans, with an MIC of 40 μg/mL.
AB - One new isochromane (pseudoanguillosporin C, 2), seven isochromanones (soudanones A-G, 3-9), and six known analogues including 10 and 11 were isolated from a culture of the fungus Cadophora sp. 10-5-2 M, collected from the subterranean 10th level of the Soudan Underground Iron Mine in Minnesota. All of the compounds were tested against a panel of microbial pathogens, and 2, 3, 10, and 11 were found to have activity against Cryptococcus neoformans (MIC = 35, 40, 20, and 30 μg/mL, respectively). Compound 11 was also active against Candida albicans, with an MIC of 40 μg/mL.
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U2 - 10.1021/acs.jnatprod.5b00204
DO - 10.1021/acs.jnatprod.5b00204
M3 - Article
C2 - 26035018
AN - SCOPUS:84933074462
SN - 0163-3864
VL - 78
SP - 1456
EP - 1460
JO - Journal of Natural Products
JF - Journal of Natural Products
IS - 6
ER -