Spatial and temporal differentiation of FMRI bold response in primary visual cortex of human brain during sustained visual simulation

Wei Chen, Xiao-Hong Zhu, Toshinori Kato, Peter Andersen, Kamil Ugurbil

Research output: Contribution to journalArticlepeer-review

39 Scopus citations

Abstract

The blood oxygenation level dependent (BOLD) response during sustained visual stimulation has been studied by several groups using fMRI with controversial conclusions. This issue was investigated for the human brain at high (4 Tesla) magnetic field strength using a flashing goggle at 8 Hz. The results demonstrate that the overall BOLD response in the primary visual cortex has an initial overshoot after the onset of visual stimulation and an undershoot after the termination of visual stimulation. A significant and positive BOLD response, how- ever, remains constant between the initial and terminal transient responses. The temporal BOLD responses in the primary visual cortex were spatially dependent. The regional identified as draining veins in images displayed proportionately larger initial and terminal transient responses, whereas regions devoid of such vessels and associated mainly with parenchyma exhibited a more time-independent BOLD response. These results reveal that the BOLD effect and, presumably, the uncoupling between cerebral blood flow and cerebral metabolic rate of oxygen consumption, are maintained in the primary visual cortex during sustained visual stimulation, and the temporal characteristics of the BOLD effect are spatially dependent.

Original languageEnglish (US)
Pages (from-to)520-527
Number of pages8
JournalMagnetic resonance in medicine
Volume39
Issue number4
DOIs
StatePublished - Apr 1 1998

Keywords

  • BOLD response
  • Primary visual cortex
  • Visual stimulation
  • fMRI

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