SPECIFIC CELL-MEDIATED IMMUNE DEFECT IN ACTIVE CYTOMEGALOVIRUS INFECTION OF YOUNG CHILDREN AND THEIR MOTHERS

Richard C. Gehrz, Susan O. Knorr, Stephen C. Marker, Janal M. Kalis, Henry H Balfour

Research output: Contribution to journalArticlepeer-review

68 Scopus citations

Abstract

4 young children with active cytomegalovirus (C.M.V.) infection were found, by an in-vitro lymphocyte-proliferation assay, to have a C.M.V.-specific cell-mediated immune defect. These children had antibodies to C.M.V. and were actively shedding C.M.V. in the urine when studied. Their general cellular immune responses were intact, with normal numbers of T lymphocytes and normal in-vitro responses to mitogens and at least one antigen. 3 of the 4 mothers studied shortly after delivery had decreased cell-mediated immunity to C.M.V. These findings suggest that an antigen-specific immune defect facilitates transmission of virus from mother to infant and permits persistence of viral replication in the offspring.

Original languageEnglish (US)
Pages (from-to)844-847
Number of pages4
JournalThe Lancet
Volume310
Issue number8043
DOIs
StatePublished - Oct 22 1977

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