Specific Frontal Lobe Deficits among Women with the Fragile X Gene

MICHÈLE M.M. MAZZOCCO, RANDI J. HAGERMAN, AMY CRONISTER-SILVERMAN, BRUCE F. PENNINGTON

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70 Scopus citations

Abstract

The neurocognitive phenotype of fragile X and its relation to cytogenetic expression were examined among 10 fragile X women with $ 2% expression, 10 0% obligate carriers, and 10 controls. Measures were obtained for intellectual ability, achievement, and verbal, nonverbal, memory, and frontal lobe functions. Results show that no group demonstrated deficits on verbal, nonverbal, or memory measures. In contrast, when controlling for effects of IQ, the expressing fragile X women exhibited (1) deficits on measures of frontal lobe functioning, and (2) enhanced performance on verbal, but not figural, memory. Frontal lobe deficits may account for behavioral and cognitive manifestations of fragile X.

Original languageEnglish (US)
Pages (from-to)1141-1148
Number of pages8
JournalJournal of the American Academy of Child and Adolescent Psychiatry
Volume31
Issue number6
DOIs
StatePublished - 1992

Keywords

  • cognitive
  • fragile X
  • frontal lobe

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