TY - JOUR
T1 - Specific Frontal Lobe Deficits among Women with the Fragile X Gene
AU - MAZZOCCO, MICHÈLE M.M.
AU - HAGERMAN, RANDI J.
AU - CRONISTER-SILVERMAN, AMY
AU - PENNINGTON, BRUCE F.
PY - 1992
Y1 - 1992
N2 - The neurocognitive phenotype of fragile X and its relation to cytogenetic expression were examined among 10 fragile X women with $ 2% expression, 10 0% obligate carriers, and 10 controls. Measures were obtained for intellectual ability, achievement, and verbal, nonverbal, memory, and frontal lobe functions. Results show that no group demonstrated deficits on verbal, nonverbal, or memory measures. In contrast, when controlling for effects of IQ, the expressing fragile X women exhibited (1) deficits on measures of frontal lobe functioning, and (2) enhanced performance on verbal, but not figural, memory. Frontal lobe deficits may account for behavioral and cognitive manifestations of fragile X.
AB - The neurocognitive phenotype of fragile X and its relation to cytogenetic expression were examined among 10 fragile X women with $ 2% expression, 10 0% obligate carriers, and 10 controls. Measures were obtained for intellectual ability, achievement, and verbal, nonverbal, memory, and frontal lobe functions. Results show that no group demonstrated deficits on verbal, nonverbal, or memory measures. In contrast, when controlling for effects of IQ, the expressing fragile X women exhibited (1) deficits on measures of frontal lobe functioning, and (2) enhanced performance on verbal, but not figural, memory. Frontal lobe deficits may account for behavioral and cognitive manifestations of fragile X.
KW - cognitive
KW - fragile X
KW - frontal lobe
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U2 - 10.1097/00004583-199211000-00025
DO - 10.1097/00004583-199211000-00025
M3 - Article
C2 - 1429419
AN - SCOPUS:0026454286
SN - 0890-8567
VL - 31
SP - 1141
EP - 1148
JO - Journal of the American Academy of Child and Adolescent Psychiatry
JF - Journal of the American Academy of Child and Adolescent Psychiatry
IS - 6
ER -