Specificity, versatility, and continual development: The power of optogenetics for epilepsy research

Zoé Christenson Wick; Esther Krook-Magnuson

doi:10.3389/fncel.2018.00151

Specificity, versatility, and continual development: The power of optogenetics for epilepsy research

Zoé Christenson Wick, Esther Krook-Magnuson

Neuroscience

Research output: Contribution to journal › Review article › peer-review

21 Scopus citations

Abstract

Optogenetics is a powerful and rapidly expanding set of techniques that use genetically encoded light sensitive proteins such as opsins. Through the selective expression of these exogenous light-sensitive proteins, researchers gain the ability to modulate neuronal activity, intracellular signaling pathways, or gene expression with spatial, directional, temporal, and cell-type specificity. Optogenetics provides a versatile toolbox and has significantly advanced a variety of neuroscience fields. In this review, using recent epilepsy research as a focal point, we highlight how the specificity, versatility, and continual development of new optogenetic related tools advances our understanding of neuronal circuits and neurological disorders. We additionally provide a brief overview of some currently available optogenetic tools including for the selective expression of opsins.

Original language	English (US)
Article number	151
Journal	Frontiers in Cellular Neuroscience
Volume	12
DOIs	https://doi.org/10.3389/fncel.2018.00151
State	Published - Jun 14 2018

Bibliographical note

Funding Information:
Work in the Krook-Magnuson lab has been supported by the National Institute of Health through grants R01-NS104071, R03-NS098015 and R00-NS087110, by the University of Minnesota’s MnDRIVE (Minnesota’s Discovery, Research and Innovation Economy) initiative, by the International Essential Tremor Foundation, the University of Minnesota’s Institute for Engineering in Medicine, the Winston and Maxine Wallin Neuroscience Discovery Fund and a McKnight Land-Grant Professorship (to EKM). ZCW was supported in part by National Institutes of Health grant T32-GM008471. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

Publisher Copyright:
© 2018 Christenson Wick and Krook-Magnuson.

Keywords

Archaerhodopsin
Cell type specificity
Channelrhodopsin
Halorhodopsin
Intersectional genetics
Neuronal circuitry
Parvalbumin
Seizures

Access

10.3389/fncel.2018.00151

OpenUrl availability

Full text

Cite this

@article{e3050b4c71d9467ea78d283ca9923dc5,

title = "Specificity, versatility, and continual development: The power of optogenetics for epilepsy research",

abstract = "Optogenetics is a powerful and rapidly expanding set of techniques that use genetically encoded light sensitive proteins such as opsins. Through the selective expression of these exogenous light-sensitive proteins, researchers gain the ability to modulate neuronal activity, intracellular signaling pathways, or gene expression with spatial, directional, temporal, and cell-type specificity. Optogenetics provides a versatile toolbox and has significantly advanced a variety of neuroscience fields. In this review, using recent epilepsy research as a focal point, we highlight how the specificity, versatility, and continual development of new optogenetic related tools advances our understanding of neuronal circuits and neurological disorders. We additionally provide a brief overview of some currently available optogenetic tools including for the selective expression of opsins.",

keywords = "Archaerhodopsin, Cell type specificity, Channelrhodopsin, Halorhodopsin, Intersectional genetics, Neuronal circuitry, Parvalbumin, Seizures",

author = "{Christenson Wick}, Zo{\'e} and Esther Krook-Magnuson",

note = "Funding Information: Work in the Krook-Magnuson lab has been supported by the National Institute of Health through grants R01-NS104071, R03-NS098015 and R00-NS087110, by the University of Minnesota{\textquoteright}s MnDRIVE (Minnesota{\textquoteright}s Discovery, Research and Innovation Economy) initiative, by the International Essential Tremor Foundation, the University of Minnesota{\textquoteright}s Institute for Engineering in Medicine, the Winston and Maxine Wallin Neuroscience Discovery Fund and a McKnight Land-Grant Professorship (to EKM). ZCW was supported in part by National Institutes of Health grant T32-GM008471. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. Publisher Copyright: {\textcopyright} 2018 Christenson Wick and Krook-Magnuson.",

year = "2018",

month = jun,

day = "14",

doi = "10.3389/fncel.2018.00151",

language = "English (US)",

volume = "12",

journal = "Frontiers in Cellular Neuroscience",

issn = "1662-5102",

publisher = "Frontiers Research Foundation",

}

TY - JOUR

T1 - Specificity, versatility, and continual development

T2 - The power of optogenetics for epilepsy research

AU - Christenson Wick, Zoé

AU - Krook-Magnuson, Esther

N1 - Funding Information: Work in the Krook-Magnuson lab has been supported by the National Institute of Health through grants R01-NS104071, R03-NS098015 and R00-NS087110, by the University of Minnesota’s MnDRIVE (Minnesota’s Discovery, Research and Innovation Economy) initiative, by the International Essential Tremor Foundation, the University of Minnesota’s Institute for Engineering in Medicine, the Winston and Maxine Wallin Neuroscience Discovery Fund and a McKnight Land-Grant Professorship (to EKM). ZCW was supported in part by National Institutes of Health grant T32-GM008471. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. Publisher Copyright: © 2018 Christenson Wick and Krook-Magnuson.

PY - 2018/6/14

Y1 - 2018/6/14

N2 - Optogenetics is a powerful and rapidly expanding set of techniques that use genetically encoded light sensitive proteins such as opsins. Through the selective expression of these exogenous light-sensitive proteins, researchers gain the ability to modulate neuronal activity, intracellular signaling pathways, or gene expression with spatial, directional, temporal, and cell-type specificity. Optogenetics provides a versatile toolbox and has significantly advanced a variety of neuroscience fields. In this review, using recent epilepsy research as a focal point, we highlight how the specificity, versatility, and continual development of new optogenetic related tools advances our understanding of neuronal circuits and neurological disorders. We additionally provide a brief overview of some currently available optogenetic tools including for the selective expression of opsins.

AB - Optogenetics is a powerful and rapidly expanding set of techniques that use genetically encoded light sensitive proteins such as opsins. Through the selective expression of these exogenous light-sensitive proteins, researchers gain the ability to modulate neuronal activity, intracellular signaling pathways, or gene expression with spatial, directional, temporal, and cell-type specificity. Optogenetics provides a versatile toolbox and has significantly advanced a variety of neuroscience fields. In this review, using recent epilepsy research as a focal point, we highlight how the specificity, versatility, and continual development of new optogenetic related tools advances our understanding of neuronal circuits and neurological disorders. We additionally provide a brief overview of some currently available optogenetic tools including for the selective expression of opsins.

KW - Archaerhodopsin

KW - Cell type specificity

KW - Channelrhodopsin

KW - Halorhodopsin

KW - Intersectional genetics

KW - Neuronal circuitry

KW - Parvalbumin

KW - Seizures

UR - http://www.scopus.com/inward/record.url?scp=85048969630&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85048969630&partnerID=8YFLogxK

U2 - 10.3389/fncel.2018.00151

DO - 10.3389/fncel.2018.00151

M3 - Review article

AN - SCOPUS:85048969630

SN - 1662-5102

VL - 12

JO - Frontiers in Cellular Neuroscience

JF - Frontiers in Cellular Neuroscience

M1 - 151

ER -

Specificity, versatility, and continual development: The power of optogenetics for epilepsy research

Abstract

Bibliographical note

Keywords

Access

OpenUrl availability

Other files and links

Fingerprint

Cite this