Spin echo functional MRI in bilateral auditory cortices at 7T: An application of B₁ shimming

Ultra high fields (UHF) permit unprecedented explorations of functional organizations and insight into basic neuronal processes. Increases in the signal and contrast to noise ratios have allowed increases in the spatial resolution of T₂^* weighted gradient echo (GE) echo planar imaging (EPI). Furthermore, while the use of T₂ weighted imaging methods at UHF (e.g. spin echo (SE) EPI, gradient and spin echo (GRASE) EPI) can also permit higher resolution images, they in addition allow for increased spatial specificity of functional responses, permitting the in-vivo study of functional organizations down to the columnar level of the cortex. The study of the visual cortex has, thus far, benefitted the most from higher resolution T₂ weighted studies as achieving the required transmit B₁ magnitude at 7T is more challenging in other brain regions, such as the auditory cortex. As such, auditory fMRI studies at UHF have been limited to T₂* weighted GE sequences. Recent advances in multi-channel RF transmission (e.g. B₁ shimming) have enabled procedures to efficiently address deficiencies in transmit B₁ profiles. However, these techniques, shown to be advantageous in anatomical imaging at UHF, are not generally utilized to facilitate T₂ weighted fMRI studies.Here we investigate the feasibility of applying B₁ shimming to achieve efficient RF transmission in the human auditory cortex. We demonstrate that, with B₁ shimming, functional responses to simple tones and to complex sounds (i.e. voices, speech, animal cries, tools and nature) can be efficiently measured with T₂ weighted SE-EPI in the bilateral human auditory cortex at 7T without exceeding specific absorption rate (SAR) limits.