Abstract
Anti-push: The axial thiolate ligand stabilizes high-spin Fe III-OOR species (see picture) such as those found in superoxide reductase. This situation is in contrast to the "push effect" observed in structurally similar low-spin FeIII-OOR systems, including cytochrome P450, which promote O-O bond cleavage. These results show how very similar enzyme-active sites can carry out two very different functions.
Original language | English (US) |
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Pages (from-to) | 584-587 |
Number of pages | 4 |
Journal | Angewandte Chemie - International Edition |
Volume | 44 |
Issue number | 4 |
DOIs | |
State | Published - Jan 14 2005 |
Keywords
- Bioinorganic chemistry
- Coordination compounds
- Iron
- Peroxides
- S ligands