Abstract
A 6 year old boy developed a fatal, rapidly progressive encephalopathy 5 months after a matched unrelated cord blood transplant. Autopsy findings revealed spongiform changes in his brain. The clinical course of this child's illness had many findings consistent with that of a transmissible spongiform encephalopathy (TSE). Pre-mortem and post-mortem studies failed to definitively determine an etiology. Spongiform encephalopathies include the TSEs and mitochondrial encephalopathies. Both should be considered in a post-hematopoietic stem cell transplant patient who develops a progressive encephalopathy when more common etiologies are not found.
Original language | English (US) |
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Pages (from-to) | 95-98 |
Number of pages | 4 |
Journal | Pediatric transplantation |
Volume | 12 |
Issue number | 1 |
DOIs | |
State | Published - Feb 2008 |
Externally published | Yes |
Keywords
- Cord blood allogeneic stem cell transplantation
- Encephalopathy
- Pediatric