Spongiform encephalopathy following allogeneic cord blood transplant

Dennis O'Brien, Kathryn Klopfenstein, Thomas G. Gross, Peter Baker, Amanda Termuhlen

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

A 6 year old boy developed a fatal, rapidly progressive encephalopathy 5 months after a matched unrelated cord blood transplant. Autopsy findings revealed spongiform changes in his brain. The clinical course of this child's illness had many findings consistent with that of a transmissible spongiform encephalopathy (TSE). Pre-mortem and post-mortem studies failed to definitively determine an etiology. Spongiform encephalopathies include the TSEs and mitochondrial encephalopathies. Both should be considered in a post-hematopoietic stem cell transplant patient who develops a progressive encephalopathy when more common etiologies are not found.

Original languageEnglish (US)
Pages (from-to)95-98
Number of pages4
JournalPediatric transplantation
Volume12
Issue number1
DOIs
StatePublished - Feb 1 2008
Externally publishedYes

Keywords

  • Cord blood allogeneic stem cell transplantation
  • Encephalopathy
  • Pediatric

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