Stable isotope labeling-mass spectrometry analysis of methyl- and pyridyloxobutyl-guanine adducts of 4-(methylnitrosamino)-1-(3-pyridyl)-1- butanone in p53-derived DNA sequences

Medicine & Life Sciences

• 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone 100%
• Isotope Labeling 93%
• Guanine 76%
• Mass Spectrometry 57%
• Deoxyguanosine 15%
• O(6)-methyl-2'-deoxyguanosine 12%
• pyrazine-2-diazohydroxide 11%
• Tumor Suppressor Genes 10%
• Codon 10%
• Mutagenesis 10%
• Carcinogens 10%
• Tobacco 10%
• High Pressure Liquid Chromatography 8%
• cytidylyl-3'-5'-guanosine 8%
• 5-Methylcytosine 7%
• DNA 5%
• Isotopes 5%
• Lung 5%
• Smokers 4%
• Lung Neoplasms 4%
• Smoking 3%
• Mutation 2%
• Neoplasms 1%

Chemical Compounds

• Stable Isotope 70%
• DNA Sequence 66%
• Guanine 62%
• Adduct 45%
• Dinucleotide 19%
• 5-Methylcytosine 13%
• Isotope 7%
• Mutation 7%
• Reaction Yield 3%