TY - JOUR
T1 - Standing frame and electrical stimulation therapies partially preserve bone strength in a rodent model of acute spinal cord injury
AU - Zamarioli, Ariane
AU - Battaglino, Ricardo A.
AU - Morse, Leslie R.
AU - Sudhakar, Supreetha
AU - Maranho, Daniel A C
AU - Okubo, Rodrigo
AU - Volpon, Jose B.
AU - Shimano, Antonio C.
PY - 2013/5/1
Y1 - 2013/5/1
N2 - Objective: The aim of this study was to compare the effect of standing frame and electrical stimulation on bone quality in a rodent transection model of spinal cord injury (SCI). DESIGN: Seven-week-old male Wistar rats were divided into four groups: sham, n = 10; SCI, n = 7; SCI + standing frame, n = 7; and SCI + electrical stimulation, n = 7. Complete SCI was generated by surgical transection of the cord at the T10 level. Therapies were initiated 3 days after the surgery, 3 days/wk, 20 mins/day, for 30 days. Animals were killed on day 33 postinjury. RESULTS: No treatment preserved bone mineral density at any skeletal site tested (P = 0.08-0.99). Standing frame therapy preserved maximal load at the lumbar vertebral body (14% vs. 37% reduction, P = 0.01) and prevented SCI-induced loss of stiffness at both the femur (8% vs. 37% reduction, P = 0.03) and the tibia (35% vs. 56% reduction, P < 0.0001). Electrical stimulation therapy reduced SCI-induced loss of stiffness at the tibia only (40% vs. 56% reduction, P = 0.003). CONCLUSIONS: Standing frame and electrical stimulation may have potential as future therapeutic modalities to treat or prevent bone loss after SCI.
AB - Objective: The aim of this study was to compare the effect of standing frame and electrical stimulation on bone quality in a rodent transection model of spinal cord injury (SCI). DESIGN: Seven-week-old male Wistar rats were divided into four groups: sham, n = 10; SCI, n = 7; SCI + standing frame, n = 7; and SCI + electrical stimulation, n = 7. Complete SCI was generated by surgical transection of the cord at the T10 level. Therapies were initiated 3 days after the surgery, 3 days/wk, 20 mins/day, for 30 days. Animals were killed on day 33 postinjury. RESULTS: No treatment preserved bone mineral density at any skeletal site tested (P = 0.08-0.99). Standing frame therapy preserved maximal load at the lumbar vertebral body (14% vs. 37% reduction, P = 0.01) and prevented SCI-induced loss of stiffness at both the femur (8% vs. 37% reduction, P = 0.03) and the tibia (35% vs. 56% reduction, P < 0.0001). Electrical stimulation therapy reduced SCI-induced loss of stiffness at the tibia only (40% vs. 56% reduction, P = 0.003). CONCLUSIONS: Standing frame and electrical stimulation may have potential as future therapeutic modalities to treat or prevent bone loss after SCI.
KW - Bone Fracture
KW - Osteoporosis
KW - Rehabilitation Medicine
KW - Spinal Cord Injury
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U2 - 10.1097/PHM.0b013e318287697c
DO - 10.1097/PHM.0b013e318287697c
M3 - Article
C2 - 23478455
AN - SCOPUS:84876838810
SN - 0894-9115
VL - 92
SP - 402
EP - 410
JO - American Journal of Physical Medicine and Rehabilitation
JF - American Journal of Physical Medicine and Rehabilitation
IS - 5
ER -