Staphylococcal toxic shock syndrome erythroderma is associated with superantigenicity and hypersensitivity

Chandy C. John; Micah Niermann; Bazak Sharon; Marnie L. Peterson; David M. Kranz; Patrick M. Schlievert

doi:10.1086/648441

Staphylococcal toxic shock syndrome erythroderma is associated with superantigenicity and hypersensitivity

Chandy C. John, Micah Niermann, Bazak Sharon, Marnie L. Peterson, David M. Kranz, Patrick M. Schlievert

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Abstract

Staphylococcal toxic shock syndrome (TSS) has rarely been reported without rash and desquamation. This study describes a patient who met all criteria for TSS except erythroderma and desquamation. The associated staphylococcal superantigen was enterotoxin B. We demonstrate that erythroderma depends on preexisting T cell hypersensitivity amplified by superantigenicity.

Original language	English (US)
Pages (from-to)	1893-1896
Number of pages	4
Journal	Clinical Infectious Diseases
Volume	49
Issue number	12
DOIs	https://doi.org/10.1086/648441
State	Published - Dec 2009

Bibliographical note

Funding Information:
Financial support. US Public Health Service research grants (U54-AI57153 from the Great Lakes Regional Center of Excellence in Biodefense and Emerging Infectious Diseases [of which P.M.S. and D.M.K. are members] and R01-AI064611 from the National Institute of Allergy and Infectious Diseases). Potential conflicts of interest. All authors: no conflicts.

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abstract = "Staphylococcal toxic shock syndrome (TSS) has rarely been reported without rash and desquamation. This study describes a patient who met all criteria for TSS except erythroderma and desquamation. The associated staphylococcal superantigen was enterotoxin B. We demonstrate that erythroderma depends on preexisting T cell hypersensitivity amplified by superantigenicity.",

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AU - Schlievert, Patrick M.

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Staphylococcal toxic shock syndrome erythroderma is associated with superantigenicity and hypersensitivity

Abstract

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