Staphylococcal toxic shock syndrome erythroderma is associated with superantigenicity and hypersensitivity

Chandy C. John, Micah Niermann, Bazak Sharon, Marnie L. Peterson, David M. Kranz, Patrick M. Schlievert

Research output: Contribution to journalArticlepeer-review

16 Scopus citations


Staphylococcal toxic shock syndrome (TSS) has rarely been reported without rash and desquamation. This study describes a patient who met all criteria for TSS except erythroderma and desquamation. The associated staphylococcal superantigen was enterotoxin B. We demonstrate that erythroderma depends on preexisting T cell hypersensitivity amplified by superantigenicity.

Original languageEnglish (US)
Pages (from-to)1893-1896
Number of pages4
JournalClinical Infectious Diseases
Issue number12
StatePublished - Dec 2009

Bibliographical note

Funding Information:
Financial support. US Public Health Service research grants (U54-AI57153 from the Great Lakes Regional Center of Excellence in Biodefense and Emerging Infectious Diseases [of which P.M.S. and D.M.K. are members] and R01-AI064611 from the National Institute of Allergy and Infectious Diseases). Potential conflicts of interest. All authors: no conflicts.

Copyright 2010 Elsevier B.V., All rights reserved.

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