Statistical analysis and modeling of pelletized cultivation of Mucor circinelloides for microbial lipid accumulation

Chunjie Xia, Wei Wei, Bo Hu

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

Microbial oil accumulation via oleaginous fungi has some potential benefits because filamentous fungi can form pellets during cell growth and these pellets are easier to harvest from the culture broth than individual cells. This research studied the effect of various culture conditions on the pelletized cell growth of Mucor circinelloides and its lipid accumulation. The results showed that cell pelletization was positively correlated to biomass accumulation; however, pellet size was negatively correlated to the oil content of the fungal biomass, possibly due to the mass transfer barriers generated by the pellet structure. How to control the size of the pellet is the key to the success of the pelletized microbial oil accumulation process.

Original languageEnglish (US)
Pages (from-to)3502-3512
Number of pages11
JournalApplied Biochemistry and Biotechnology
Volume172
Issue number7
DOIs
StatePublished - Apr 2014

Bibliographical note

Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.

Keywords

  • Fungal pelletization
  • Microbial lipid accumulation
  • Mucor circinelloides

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