Stem cells in skeletal muscle regeneration

Research output: Chapter in Book/Report/Conference proceedingChapter


Skeletal muscle is a highly regenerative tissue in the adult vertebrate body. Adult muscle contains muscle satellite cells (myogenic stem cells) which give rise to daughter myogenic precursor cells (myoblasts) in adult skeletal muscle, where they function in postnatal tissue growth and regeneration. Satellite cells are normally mitotically quiescent. Following injury, they initiate proliferation to produce their progeny of myoblasts to mediate the regeneration of muscle. Adult skeletal muscle also contains a novel stem cell population purified as a side population (SP), which actively excludes Hoechst 33342 dye. Muscle SP cells that express the stem cell marker Sca-1 possess the ability to differentiate into myogenic precursor cells, as well as satellite cells following transplantation. Recent work demonstrates that the heart also contains a novel stem cell-like cell population purified as SP/Sca-1+ cells. Thus, these novel cardiac stem/progenitor cells that can participate in heart regeneration appear to have similar characteristics to muscle SP cells. In this article, I outline recent findings regarding stem cell populations in skeletal muscle and their involvement in muscle regeneration. In addition, I discuss cardiac stem/progenitor cells and their similarity to muscle SP cells.

Original languageEnglish (US)
Title of host publicationStem Cells and Regenerative Medicine
PublisherWorld Scientific Publishing Co.
Number of pages31
ISBN (Electronic)9789812775771
ISBN (Print)9812775765, 9789812775764
StatePublished - Jan 1 2008


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