TY - JOUR
T1 - Stereochemical Studies on Medicinal Agents. 24 Correlation of the Solid‐State Conformations of 4‐Phenylpiperidine Analgetic With the Torsional Relationship Between the Phenyl Group and Piperidine Ring in Solution, a Circular Dichroism Study
AU - Poupaert, Jacques H.
AU - Portoghese, Philip S.
PY - 1977
Y1 - 1977
N2 - A CD study of 8 representatives of 4‐phenylpiperidine analgetics is presented to correlate their solid‐state conformations with their chiroptical properties in solution. In addition to the benzenoid 1Lb fingerprint, the studied compounds exhibit two waves: the former band around 230‐223 nm is assigned to a 1La transition; the origin of the latter band is not determined. A quadrant rule is tentatively proposed to explain the sign of the 1La Cotton effect.
AB - A CD study of 8 representatives of 4‐phenylpiperidine analgetics is presented to correlate their solid‐state conformations with their chiroptical properties in solution. In addition to the benzenoid 1Lb fingerprint, the studied compounds exhibit two waves: the former band around 230‐223 nm is assigned to a 1La transition; the origin of the latter band is not determined. A quadrant rule is tentatively proposed to explain the sign of the 1La Cotton effect.
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U2 - 10.1002/bscb.19770861106
DO - 10.1002/bscb.19770861106
M3 - Article
AN - SCOPUS:84982442837
SN - 0037-9646
VL - 86
SP - 863
EP - 867
JO - Bulletin des Sociétés Chimiques Belges
JF - Bulletin des Sociétés Chimiques Belges
IS - 11
ER -