Reaction of baccatin III and paclitaxel with samarium diiodide yielded the corresponding 10-deacetyl-9β-hydroxy derivatives. When 10-deacetylbaccatin III and docetaxel were subjected to the same reaction conditions the corresponding 9β-hydroxy and 10-dehydroxy-9β-hydroxy analogues were isolated.
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Acknowledgements: We gratefully acknowledge financial support from the National Institutes of Health (CA55160 and CA55141). Support is also acknowledged from the Kansas Health Foundation for a postdoctoral fellowship awarded to Z. S. Cheruvallath. Dr. S. M. Ali is acknowledged for providing a sample of docetaxel for these studies, Dr. M. Morton and Dr. S. M. Ali for their help with the NMR studies, and Drs. G. C. B. Harriman and T. C. Boge for helpful discussions. Paclitaxel and a mixture of paelitaxel and cephalomannine were provided to us for these studies by the National Cancer Institute.
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