Stereospecific binding of narcotics to brain cerebrosides

Horace H. Loh; Mook Cho Tae Mook Cho; Wu Ya-Chen Wu; E. Leong Way

doi:10.1016/0024-3205(74)90105-2

Stereospecific binding of narcotics to brain cerebrosides

Horace H. Loh, Mook Cho Tae Mook Cho, Wu Ya-Chen Wu, E. Leong Way

Pharmacology

Research output: Contribution to journal › Article › peer-review

73 Scopus citations

Abstract

Cerebrosides were shown to bind etorphine and naloxone stereo-specifically with high affinity. The relative potency of several narcotic analgesics in preventing the binding of etorphine and naloxone to cerebrosides correlated well with their reported intraventricular analgetic activity. The data indicate similarities between cerebroside sulfate and a purified opiate receptor from mouse brain which has been reported to be a proteolipid. Explanations for the apparent proteo-like behavior of the opiate receptor are provided.

Original language	English (US)
Pages (from-to)	2231-2245
Number of pages	15
Journal	Life Sciences
Volume	14
Issue number	11
DOIs	https://doi.org/10.1016/0024-3205(74)90105-2
State	Published - Jun 1 1974

Bibliographical note

Funding Information:
This investigation was supported by the U.S . Army Medical Research and Development Command under Contract No . DADA17-73-C-3006 .

Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.

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title = "Stereospecific binding of narcotics to brain cerebrosides",

abstract = "Cerebrosides were shown to bind etorphine and naloxone stereo-specifically with high affinity. The relative potency of several narcotic analgesics in preventing the binding of etorphine and naloxone to cerebrosides correlated well with their reported intraventricular analgetic activity. The data indicate similarities between cerebroside sulfate and a purified opiate receptor from mouse brain which has been reported to be a proteolipid. Explanations for the apparent proteo-like behavior of the opiate receptor are provided.",

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note = "Funding Information: This investigation was supported by the U.S . Army Medical Research and Development Command under Contract No . DADA17-73-C-3006 . Copyright: Copyright 2014 Elsevier B.V., All rights reserved.",

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AU - Tae Mook Cho, Mook Cho

AU - Ya-Chen Wu, Wu

AU - Leong Way, E.

N1 - Funding Information: This investigation was supported by the U.S . Army Medical Research and Development Command under Contract No . DADA17-73-C-3006 . Copyright: Copyright 2014 Elsevier B.V., All rights reserved.

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Y1 - 1974/6/1

N2 - Cerebrosides were shown to bind etorphine and naloxone stereo-specifically with high affinity. The relative potency of several narcotic analgesics in preventing the binding of etorphine and naloxone to cerebrosides correlated well with their reported intraventricular analgetic activity. The data indicate similarities between cerebroside sulfate and a purified opiate receptor from mouse brain which has been reported to be a proteolipid. Explanations for the apparent proteo-like behavior of the opiate receptor are provided.

AB - Cerebrosides were shown to bind etorphine and naloxone stereo-specifically with high affinity. The relative potency of several narcotic analgesics in preventing the binding of etorphine and naloxone to cerebrosides correlated well with their reported intraventricular analgetic activity. The data indicate similarities between cerebroside sulfate and a purified opiate receptor from mouse brain which has been reported to be a proteolipid. Explanations for the apparent proteo-like behavior of the opiate receptor are provided.

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Stereospecific binding of narcotics to brain cerebrosides

Abstract

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