Stimulated growth of human and pig epidermal nerve fibers by tape stripping

Mona M. Selim, Kathy A. Wabner, Gwen Wendelschafer-Crabb, William R. Kennedy

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Nerve growth studies in adults usually rely upon nerve regeneration that follows axon disruption. In this study elongation of the epidermal nerve fibers occurred in human and pig epidermis stimulated to hypertrophy by removing the stratum corneum with repetitive applications of tape (tape stripping). Epidermal thickening was accompanied by elongation of the epidermal nerve fibers. This study demonstrates that changing the cellular and chemical environment of nerves by tape stripping is a feasible method to study nerve fiber growth in a physiological manner.

Original languageEnglish (US)
Pages (from-to)513-516
Number of pages4
JournalArchives of Dermatological Research
Volume299
Issue number10
DOIs
StatePublished - Dec 2007

Keywords

  • Immunohistochemistry
  • Nerve growth
  • PGP 9.5
  • Tape stripping

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