Stimulation history dictates memory CD8 T cell phenotype: Implications for prime-boost vaccination

David Masopust, Sang Jun Ha, Vaiva Vezys, Rafi Ahmed

Research output: Contribution to journalArticlepeer-review

224 Scopus citations

Abstract

Heterologous prime-boost vaccination results in increased frequencies of memory T cells. Although these quantitative effects of reexposure to Ag are well documented, little is known about the impact of boosting on the functional qualities of memory T cells. To address this critical issue, we have used three different types of immunization regimens and examined how boosting effects the function and anatomic location of memory CD8 T cells. We found that memory T cell phenotype differed substantially depending on the number of immunizations and that secondary and tertiary responses resulted in the generation of memory CD8 T cells that retained effector-like properties and showed preferential accumulation in nonlymphoid tissues. These results show that memory differentiation is coupled to the history of Ag experience and that prime-boost vaccination strategies have important consequences on memory CD8 T cell quality and surveillance within mucosal tissues.

Original languageEnglish (US)
Pages (from-to)831-839
Number of pages9
JournalJournal of Immunology
Volume177
Issue number2
DOIs
StatePublished - Jul 15 2006

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