Strategies to Prevent or Remediate Cancer and Treatment-Related Aging

Jennifer L. Guida, Tanya Agurs-Collins, Tim A. Ahles, Judith Campisi, William Dale, Wendy Demark-Wahnefried, Jorg Dietrich, Rebecca Fuldner, Lisa Gallicchio, Paige A. Green, Arti Hurria, Michelle C. Janelsins, Chamelli Jhappan, James L. Kirkland, Ronald Kohanski, Valter Longo, Simin Meydani, Supriya Mohile, Laura J. Niedernhofer, Christian NelsonFrank Perna, Keri Schadler, Jessica M. Scott, Jennifer A. Schrack, Russell P. Tracy, Jan Van Deursen, Kirsten K. Ness

Research output: Contribution to journalReview articlepeer-review

Abstract

Up to 85% of adult cancer survivors and 99% of adult survivors of childhood cancer live with an accumulation of chronic conditions, frailty, and/or cognitive impairments resulting from cancer and its treatment. Thus, survivors often show an accelerated development of multiple geriatric syndromes and need therapeutic interventions. To advance progress in this area, the National Cancer Institute convened the second of 2 think tanks under the auspices of the Cancer and Accelerated Aging: Advancing Research for Healthy Survivors initiative. Experts assembled to share evidence of promising strategies to prevent, slow, or reverse the aging consequences of cancer and its treatment. The meeting identified research and resource needs, including geroscience-guided clinical trials; comprehensive assessments of functional, cognitive, and psychosocial vulnerabilities to assess and predict age-related outcomes; preclinical and clinical research to determine the optimal dosing for behavioral (eg, diet, exercise) and pharmacologic (eg, senolytic) therapies; health-care delivery research to evaluate the efficacy of integrated cancer care delivery models; optimization of intervention implementation, delivery, and uptake; and patient and provider education on cancer and treatment-related late and long-term adverse effects. Addressing these needs will expand knowledge of aging-related consequences of cancer and cancer treatment and inform strategies to promote healthy aging of cancer survivors.

Original languageEnglish (US)
Pages (from-to)112-122
Number of pages11
JournalJournal of the National Cancer Institute
Volume113
Issue number2
DOIs
StatePublished - Feb 1 2021

Bibliographical note

Funding Information:
This work was supported by the National Institutes of Health (R01CA172119, R01CA129769, U54CA137788, R01CA218496, R01CA129769, and P30CA008748 to TAA; R21/R33AG059206 to WD, SGM, and AH; DP2CA195765 and R01CA231014 to MCJ; R37AG013925 and R33AG061456 to JLK; P01AG062413 to JLK and LJN; P30AG021334, U01AG020478, U01AG020487, U01AG020480 to SNM; K24AG056589 to SGM; AG043376 and AG056278 LJN; R21CA218732 to KS; R21AG053198 and U01AG057545 to JAS; P30CA008748 to JMS; and R01AG052964 to RT), USDA (Agreement # 58-1950-0-014 and 58-805-9-004 to SNM), the American Cancer Society (CRP 14-111-01-CPPB to WDW), and AKTIV Against Cancer (JMS).

Publisher Copyright:
© 2020 Published by Oxford University Press.

PubMed: MeSH publication types

  • Journal Article
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

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