Abstract
The interaction of endogenous opiates and stress-induced eating in rats was evaluated by pharmacological manipulation. Eating induced by the tail-pinch method was inhibited by the opiate antagonist naloxone; after being repeatedly stressed over a 10-day period and then given naloxone, the rats behaved in a manner indistinguishable from the "wet-dog" shakes of opiate withdrawal. Thus endogenous opiates may have a role in the control of stress-related eating, a finding that may have therapeutic implications for humans.
Original language | English (US) |
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Pages (from-to) | 1259-1261 |
Number of pages | 3 |
Journal | Science |
Volume | 209 |
Issue number | 4462 |
DOIs | |
State | Published - Jan 1 1980 |