Striatal cholinergic interneurons are a novel target of corticotropin releasing factor

Julia C. Lemos, Jung Hoon Shin, Veronica A. Alvarez

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Cholinergic interneurons (CINs) are critical regulators of striatal network activity and output. Changes in CIN activity are thought to encode salient changes in the environment and stimulus–response– outcome associations. Here we report that the stress-associated neuropeptide corticotropin releasing factor (CRF) produces a profound and reliable increase in the spontaneous firing of CINs in both dorsal striatum and nucleus accumbens (NAc) through activation of CRF type 1 receptors, production of cAMP and reduction in spike accommodation in male mice. The increase of CIN firing by CRF results in the activation muscarinic acetylcholine receptors type 5, which mediate potentiation of dopamine transmission in the striatum. This study provides critical mechanistic insight into how CRF modulates striatal activity and dopamine transmission in the NAc to likely account for CRF facilitation of appetitive behaviors.

Original languageEnglish (US)
Pages (from-to)5647-5661
Number of pages15
JournalJournal of Neuroscience
Volume39
Issue number29
DOIs
StatePublished - Jul 17 2019

Bibliographical note

Publisher Copyright:
Copyright © 2019 the authors.

Keywords

  • Acetylcholine
  • Dopamine transmission
  • Muscarinic receptors
  • Nucleus accumbens
  • Striatum

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