Structural basis for activation of the autoinhibitory C-terminal kinase domain of p90 RSK2

Margarita L Malakhova, Valentina Tereshko, Sung-Young Lee, Ke Yao, Yong Yeon Cho, Ann Bode, Zigang Dong

Research output: Contribution to journalArticlepeer-review

37 Scopus citations

Abstract

The X-ray structure at 2.0-Å resolution of the p90 ribosomal S6 kinase 2 C-terminal kinase domain revealed a C-terminal autoinhibitory αL-helix that was embedded in the kinase scaffold and determines the inactive kinase conformation. We suggest a mechanism of activation through displacement of the αL-helix and rearrangement of the conserved residue Glu500, as well as the reorganization of the T-loop into the active conformation.

Original languageEnglish (US)
Pages (from-to)112-113
Number of pages2
JournalNature Structural and Molecular Biology
Volume15
Issue number1
DOIs
StatePublished - Jan 2008

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