TY - JOUR
T1 - Structural basis of ventricular remodeling
T2 - role of the myocyte.
AU - Li, Faqian
AU - Wang, Xuejun
AU - Yi, Xian Ping
AU - Gerdes, A. Martin
PY - 2004
Y1 - 2004
N2 - Structural remodeling plays a major role in the progression of various heart diseases to congestive heart failure (CHF). Major contributors to this remodeling process in the heart include alterations in myocyte shape, myocyte number, and extracellular matrix. However, it is unclear as to which of these changes is most critical in the development of CHF, and this may vary by etiology. Myocyte shape alterations largely underlie the increase in chamber diameter/wall thickness characteristic of CHF. This review mainly focuses on the role of myocyte shape in ventricular remodeling. Several signaling molecules have been implicated in this process. As we learn more about the components of myocardial remodeling, new strategies to combat the progression of heart disease should arise.
AB - Structural remodeling plays a major role in the progression of various heart diseases to congestive heart failure (CHF). Major contributors to this remodeling process in the heart include alterations in myocyte shape, myocyte number, and extracellular matrix. However, it is unclear as to which of these changes is most critical in the development of CHF, and this may vary by etiology. Myocyte shape alterations largely underlie the increase in chamber diameter/wall thickness characteristic of CHF. This review mainly focuses on the role of myocyte shape in ventricular remodeling. Several signaling molecules have been implicated in this process. As we learn more about the components of myocardial remodeling, new strategies to combat the progression of heart disease should arise.
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U2 - 10.1007/s11897-004-0010-y
DO - 10.1007/s11897-004-0010-y
M3 - Review article
C2 - 16036018
AN - SCOPUS:24044495584
SN - 1546-9530
VL - 1
SP - 5
EP - 8
JO - Current Heart Failure Reports
JF - Current Heart Failure Reports
IS - 1
ER -