Abstract
NMR spectroscopy and X-ray crystallography in conjunction with extended X-ray absorption fine structure spectroscopy, have contributed to the elucidation of the structural biology of protein-mediated mechanisms of heavy metal homeostasis. Among the most striking aspects of these investigations are the remarkable similarity of metal-ion-transport and sequestering systems across different species, and the need to continue the research to confirm hypotheses for the molecular mechanisms of transfers of metal ions between proteins.
Original language | English (US) |
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Pages (from-to) | 217-223 |
Number of pages | 7 |
Journal | Current opinion in chemical biology |
Volume | 6 |
Issue number | 2 |
DOIs | |
State | Published - Apr 1 2002 |
Bibliographical note
Funding Information:We thank R Steele, A Prantner, G Porcelli, Y Coppel and D Brabazon for their participation in the research described in this article. This research was supported by grants R823576 from the Environmental Protection Agency, DE-F607-97ER62314 from the Department of Energy, and RO1GM29754 and P41RR09793 from the National Institutes of Health.