Structure-activity studies of some berberine analogs as inhibitors of Toxoplasma gondii

Bogdana Krivogorsky, Jennifer A. Pernat, Kelsi A. Douglas, Nikolas J. Czerniecki, Peter Grundt

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

The shortfalls of the current treatment options against infections with the parasite Toxoplasma gondii (T. gondii) necessitates the development of non-toxic and well-tolerated alternatives. To address this problem a structurally diverse panel of berberine alkaloids was synthesized and evaluated for in vitro inhibition of T. gondii tachyzoites. Inhibitory doses (ID 50) of less than 50 nM and therapeutic indices (TI) up to 4000 were observed.

Original languageEnglish (US)
Pages (from-to)2980-2982
Number of pages3
JournalBioorganic and Medicinal Chemistry Letters
Volume22
Issue number8
DOIs
StatePublished - Apr 15 2012

Bibliographical note

Funding Information:
Funds for this work were provided by the University of Minnesota Undergraduate Research Opportunity Program and the Swenson Family. We also acknowledge Matthew Rodstein for critically reading an earlier version of this manuscript.

Copyright:
Copyright 2012 Elsevier B.V., All rights reserved.

Keywords

  • Antiparasitic activity
  • Berberine
  • Toxoplasma gondii

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