Abstract
DNA replication is necessary for
the transmission of genetic information and
thus such a process must achieve accurate
copying of the genome. Since the last century
the replicon model has been proposed in order
to explain the general mechanism of genome
duplication in bacteria. Later work in yeast lead
to identifying proteins and dna sequences
that participate in the initiation of replication
in a similar fashion to what has been observed
in prokaryotes. This led to attempts for
generalizing the replicon model to eukaryotes.
Several key factors involved in replication
and conserved from yeast to man have been
described to date. However, as yet, it is not
understood how are determined the sites for
the start of replication nor the structure of
actual replicons in metazoans. In this article it
is suggested that the topological organization
of dna within the cell nucleus determines the
structure and function of replicons in higher
eukaryotes.
the transmission of genetic information and
thus such a process must achieve accurate
copying of the genome. Since the last century
the replicon model has been proposed in order
to explain the general mechanism of genome
duplication in bacteria. Later work in yeast lead
to identifying proteins and dna sequences
that participate in the initiation of replication
in a similar fashion to what has been observed
in prokaryotes. This led to attempts for
generalizing the replicon model to eukaryotes.
Several key factors involved in replication
and conserved from yeast to man have been
described to date. However, as yet, it is not
understood how are determined the sites for
the start of replication nor the structure of
actual replicons in metazoans. In this article it
is suggested that the topological organization
of dna within the cell nucleus determines the
structure and function of replicons in higher
eukaryotes.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 269-286 |
| Number of pages | 18 |
| Journal | Ciencia Ergo Sum |
| Volume | 15 |
| Issue number | 3 |
| State | Published - 2008 |