Structures and biological activities of novel antibiotic peptaibols neoatroviridins A-D from Trichoderma atroviride F80317

Seung Uk Oh, Bong Sik Yun, Sang Jun Lee, Ick Dong Yoo

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11 Scopus citations

Abstract

Four new antibiotic peptaibols, named neoatroviridins A (1), B (2), C (3), and D (4), have been isolated from the culture broth of Trichoderma atroviride. Their amino acid sequences were determined mainly by mass spectrometry in combination with NMR studies. The absolute stereochemistry of neoatroviridins was established as L by GC analysis of their acid hydrolysates with derivatization, except for isovaline which was in D. Neoatroviridins, composed of 18 amino acid residues, showed significant membrane-perturbing activity responsible for their antibiotic action, which was comparable to that of alamethicin, a well-known 20-residue peptaibol.

Original languageEnglish (US)
Pages (from-to)384-387
Number of pages4
JournalJournal of Microbiology and Biotechnology
Volume15
Issue number2
StatePublished - Apr 1 2005

Keywords

  • Membrane-perturbing activity
  • Neoatroviridins
  • Peptaibol antibiotic
  • Structure determination
  • Trichoderma atroviride

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