Studies of lysosomal function: I. Metabolism of some complex lipids by isolated hepatocytes and Kupffer cells

John A. Barranger, Peter G. Pentchev, F. Scott Furbish, Clifford J. Steer, E. Anthony Jones, Roscoe O. Brady

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

The enzymatic hydrolysis of four complex lipids was measured in extracts of rat hepatocytes and Kupffer cells. Sphingomyelin, glucocerebroside, ceramide trihexoside, and GMl-ganglioside were hydrolyzed by extracts of both cell types. Hepatocytes contain 90% or more of the complex lipid hydrolases present in liver. The activities of ten additional acid hydrolases are located predominately in hepatocytes with only a small fraction of the total activity present in Kupffer cells.

Original languageEnglish (US)
Pages (from-to)1055-1060
Number of pages6
JournalBiochemical and Biophysical Research Communications
Volume83
Issue number3
DOIs
StatePublished - Aug 14 1978

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