The enzymatic hydrolysis of four complex lipids was measured in extracts of rat hepatocytes and Kupffer cells. Sphingomyelin, glucocerebroside, ceramide trihexoside, and GMl-ganglioside were hydrolyzed by extracts of both cell types. Hepatocytes contain 90% or more of the complex lipid hydrolases present in liver. The activities of ten additional acid hydrolases are located predominately in hepatocytes with only a small fraction of the total activity present in Kupffer cells.
|Original language||English (US)|
|Number of pages||6|
|Journal||Biochemical and Biophysical Research Communications|
|State||Published - Aug 14 1978|