Studies on the biosynthesis of the mitomycin antibiotics by Streptomyces verticillatus

U. Hornemann; J. C. Cloyd

doi:10.1039/C29710000301

Studies on the biosynthesis of the mitomycin antibiotics by Streptomyces verticillatus

U. Hornemann, J. C. Cloyd

Experimental and Clinical Pharmacology

Research output: Contribution to journal › Article › peer-review

26 Scopus citations

Abstract

Biosynthetic studies indicate that the mitomycins are not formed from aromatic precursors, but that Me-^-14C-L-methionine and guanido- ¹⁴C-L-arginine specifically label peripheral substituents and that glucosamine is probably incorporated intact into a C₆-fragment of these antibiotics.

Original language	English (US)
Pages (from-to)	301-302
Number of pages	2
Journal	Journal of the Chemical Society D: Chemical Communications
Issue number	7
DOIs	https://doi.org/10.1039/C29710000301
State	Published - Dec 1 1971

Access

10.1039/C29710000301

OpenUrl availability

Full text

Cite this

@article{8721ac9405b44c76ad4f7e117c53cf75,

title = "Studies on the biosynthesis of the mitomycin antibiotics by Streptomyces verticillatus",

abstract = "Biosynthetic studies indicate that the mitomycins are not formed from aromatic precursors, but that Me--14C-L-methionine and guanido- 14C-L-arginine specifically label peripheral substituents and that glucosamine is probably incorporated intact into a C6-fragment of these antibiotics.",

author = "U. Hornemann and Cloyd, {J. C.}",

year = "1971",

month = dec,

day = "1",

doi = "10.1039/C29710000301",

language = "English (US)",

pages = "301--302",

journal = "Journal of the Chemical Society D: Chemical Communications",

issn = "0577-6171",

publisher = "Royal Society of Chemistry",

number = "7",

}

TY - JOUR

T1 - Studies on the biosynthesis of the mitomycin antibiotics by Streptomyces verticillatus

AU - Hornemann, U.

AU - Cloyd, J. C.

PY - 1971/12/1

Y1 - 1971/12/1

N2 - Biosynthetic studies indicate that the mitomycins are not formed from aromatic precursors, but that Me--14C-L-methionine and guanido- 14C-L-arginine specifically label peripheral substituents and that glucosamine is probably incorporated intact into a C6-fragment of these antibiotics.

AB - Biosynthetic studies indicate that the mitomycins are not formed from aromatic precursors, but that Me--14C-L-methionine and guanido- 14C-L-arginine specifically label peripheral substituents and that glucosamine is probably incorporated intact into a C6-fragment of these antibiotics.

UR - http://www.scopus.com/inward/record.url?scp=34249093867&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34249093867&partnerID=8YFLogxK

U2 - 10.1039/C29710000301

DO - 10.1039/C29710000301

M3 - Article

AN - SCOPUS:34249093867

SN - 0577-6171

SP - 301

EP - 302

JO - Journal of the Chemical Society D: Chemical Communications

JF - Journal of the Chemical Society D: Chemical Communications

IS - 7

ER -

Studies on the biosynthesis of the mitomycin antibiotics by Streptomyces verticillatus

Abstract

Access

OpenUrl availability

Other files and links

Fingerprint

Cite this