Study of constancy of hydrogen-consuming flora of human colon

Alessandra Strocchi, Carol J. Ellis, Julie K. Furne, Michael D. Levitt

Research output: Contribution to journalArticlepeer-review

18 Scopus citations


The constancy of the hydrogen consuming flora of the human colon was studied in 15 healthy subjects via two measurements obtained 18 to 36 months apart. Hydrogen disappearance rate and the major products of H2-consuming bacteria, methane and sulfide, were measured during incubation of fecal homogenates with excess hydrogen and sulfate. In 11/15, the hydrogen consumption rate and the predominant hydrogen-consuming pathway (methanogenesis, sulfate reduction, or neither) remained constant. However, major shifts in these pathways were observed in four subjects, with two losing and two gaining the ability to produce methane. Methanogenesis was associated with the highest hydrogen consumption rate. This study demonstrates that clinically unrecognizable, major alterations of the colonic flora occur in healthy subjects. Understanding of the factors responsible for these alterations might allow for therapeutic manipulation of the colonic flora.

Original languageEnglish (US)
Pages (from-to)494-497
Number of pages4
JournalDigestive Diseases and Sciences
Issue number3
StatePublished - Mar 1994


  • human colonic flora
  • hydrogen consumption
  • methane
  • sulfate-reducing bacteria

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