TY - GEN
T1 - Subclinical cardiovascular disease markers applicable to studies of oral health
T2 - Multiethnic study of atherosclerosis
AU - Jacobs Jr, David R
AU - Crow, Richard S.
PY - 2007/3
Y1 - 2007/3
N2 - Recent findings associate periodontal disease with established coronary heart disease (CHD) and with disorders of the carotid artery. Besides measures of the carotid artery, a number of other noninvasive subclinical markers of cardiovascular disease exist and are summarized here. Included are computed tomography (CT) of the coronary arteries, ultrasound of the carotid arteries, echocardiography, magnetic resonance imaging (MRI), ankle-brachial index, microalbuminuria, and other biochemical measures of kidney dysfunction, flow-mediated dilation in the brachial artery, and pulse wave form analysis. Use of these measures may simplify and add depth to studies of oral health and cardiovascular disease. However, it is noted that the measures are not highly correlated with each other (based on 6,814 persons in the Multiethnic Study of Atherosclerosis, Pearson correlations among the above subclinical measures, range from about 0.1-0.4), do not include propensity for the important atherosclerotic phase of plaque rupture, and do not fully substitute for studies of clinical cardiovascular disease endpoints.
AB - Recent findings associate periodontal disease with established coronary heart disease (CHD) and with disorders of the carotid artery. Besides measures of the carotid artery, a number of other noninvasive subclinical markers of cardiovascular disease exist and are summarized here. Included are computed tomography (CT) of the coronary arteries, ultrasound of the carotid arteries, echocardiography, magnetic resonance imaging (MRI), ankle-brachial index, microalbuminuria, and other biochemical measures of kidney dysfunction, flow-mediated dilation in the brachial artery, and pulse wave form analysis. Use of these measures may simplify and add depth to studies of oral health and cardiovascular disease. However, it is noted that the measures are not highly correlated with each other (based on 6,814 persons in the Multiethnic Study of Atherosclerosis, Pearson correlations among the above subclinical measures, range from about 0.1-0.4), do not include propensity for the important atherosclerotic phase of plaque rupture, and do not fully substitute for studies of clinical cardiovascular disease endpoints.
KW - Ankle-brachial index
KW - Carotid artery wall thickness
KW - Coronary calcium
KW - Magnetic resonance imaging
KW - Periodontitis
KW - Urinary albumin
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U2 - 10.1196/annals.1384.029
DO - 10.1196/annals.1384.029
M3 - Conference contribution
C2 - 17435135
AN - SCOPUS:34248222631
SN - 157331661X
SN - 9781573316613
T3 - Annals of the New York Academy of Sciences
SP - 269
EP - 287
BT - Oral-based Diagnostics
PB - Blackwell Publishing Inc
ER -
